Wild Burmese pythons are considered threatened and vulnerable. Populations are declining due to habitat destruction, as well as selling animals for their skin and as food.
As a non-native species, Burmese pythons are an invasive nuisance. Pet owners unprepared for the responsibility have been known to release snakes into the wild, where they can cause severe damage to native mammal populations.
A substantial population of freed pet snakes has become established in the Everglades National Park where they have cause great harm to local animal numbers. A study done in 2012 showed that many species including raccoons, possums and bobcats had been reduced by up to 99% in some cases, and other animals such as foxes and rabbits have all but disappeared.