Acrocanthosaurus lived in the Early Cretaceous Period, from125 to 100 million years ago, in what is now North America. Its remains are mainly known from Oklahoma, Texas and Wyoming, though it may have had a much larger range.
Its habitat was a large coastal floodplain, and it may have frequented many different environments. In addition to long-necked sauropods and duck-billed ornithopods, it also shared a habitat with the smaller predator Deinonychus. Due to differences in their size, they likely did not compete with one another.